Bioreactor, Fermentor Bioreactor, Bioreactor Fermentor manufacturer / supplier in China, offering 20L 30L 50L Stainless Steel and Glass Industrial Fermentor Bioreactor, 30L 50L 100L Stainless Steel Food Grade Laboratory Bio Fermenter, Autoclave Biologics Microbiology 5L 7L 10L Lab Glass Reactor and so on.
Bioreactor
Bioreactors of full mixing are intended for suspension cultivation of microorganisms, barmy and fungal cultures, and also initial compositions of medicines.
Biological reactors are manufactured of high-quality stainless steel according to the specification of the customer, in the set parameters, for intensive hashing are supplied with mixer with the electric drive, equipped with the control panel on 2 capacities
Bioreactors can be used for industrial production of different pharmaceutical means, medicinal and veterinary preparations, different vaccines, in the food industry for production of enzymes, food additives, glucosic syrups, etc.
Biological reactors are widely used in the biotechnology industry.
Bioreactor is an apparatus, such as a fermentation chamber, for growing organisms such as bacteria or yeast that are used in the biotechnological production of substances such as pharmaceuticals, antibodies, or vaccines, or for the bioconversion of organic waste.
Bioreactor is a fermentation vat for the production of living organisms, as bacteria or yeast.
The stainless steel (SUS316L) vessel and the whole attachments can be sterilized automatically or manually in this plant scale fermentation system and the whole fermentation process can be performed automatically also. The monitoring and controlling system is selectable for integrated monitoring / controlling board of Silver Double Limited or any kinds of modular system.
The master monitoring and controlling systems can be supplied for the ordered specification and PC based monitoring system is the standard specifications.
· Very easy to operate, wash and make maintenance as it has the open frame structure and uses stainless steel (SUS316L) plate.
· The pH, DO, temperature and rotation speed of the agitator are measured and controlled by the integrated controller system.
Temperature of the vessel is measured by the RTD (Pt-100) and controlled by the digital PID control algorithm. The air driven diaphragm style valve protects for the contamination and easy to clean and make maintenance.
Vessel
· Stainless steel (SUS316L) is used to prevent contamination and rusting.
· Water jacket system is adopted for precise temperature control.
· Redundant ports are installed on the head plate that the auxiliary sensor can be installed.
· Sensor ports are installed in the circumferential direction on the lower side of the vessel.
Controller System
· Monitoring and controlling system is selectable and the integrated controller board of SiDoLim is standard specification but any kinds of monitoring and/or controlling module can be adopted.
· Standard control system is the same as that of pilot scale system.
· Personal computer based monitoring system is the standard specification for the master monitoring and controlling system but any kinds of the order made system is possible also.
Equipment |
Item |
Requirements and manufacturers |
3000L
fermenter |
Fermenter body |
The size of fermenter takes in general use type as basis and The main material of the fermenter is made by 316L stainless steel. The design pressure: P(inside)= 0.3Mpa, P(interlayer)= 0.3Mpa, The polishing precision: Ra0.4~0.6, the ratio between diameter and height: 1:2.8 |
Sterilization method |
Auto sterilizing in situ(SIP) |
|
Stirring system |
Mechanical sealing system at the top of the fermenter; high-powered stirring oar, antifoam oar; AC electrical machine(SEW): infinite speed variation; rpm in the 6000L fermenter: 50~300rpm±1%, infinite speed regulated by transducer. The height of the stirring oar can be adjusted, too. |
|
Temperature detection and control |
Heat by thermostatic water tank and circulate by circulating pump(Grundfos, Denmark), autocontrol (cooling water+5℃)~70℃±0.1℃,temperature probe(imported) |
|
pH detection and control |
2.00-12.00±0.05pH, autocontrol by adding acid and base, pH sensor (Mettler, Switzerland) and shielding lead (Mettler, Switzerland). 6000L fermenter is autocontrolled with pneumatic diaphragm cell valve(BURKERT, Germany) |
|
DO detection and control |
0-150±3% displaying precision 0.1%, sensor (Mettler, Switzerland) and shielding lead(Mettler, Switzerland) |
|
Feed control |
3000L fermenter uses pneumatic diaphragm cell valve(BURKERT, Germany). |
|
Antifoam control |
Tested by sencor and added antifoamer by peristaltic pump (Longer). |
|
Aeration detection and control |
automanual control ventilatory capacity, the precision of nhaler : 0.1μ, displayed by rotameter. The range of flow adjusting of 6000L fermenter: 0~12000L/min |
|
pressure detection and control |
autoManual control exhaust by diaphragm cell valve(BURKERT, Germany) and displayed by pressure gauge. |
|
Pipeline and valve |
The pipelines and valves which are in contact with the zymotic fluid are made by 316L stainless steel, the valves are diaphragm cell valves(BURKERT, Germany). |
|
Control system |
Control System: on-site controller, the next crew for the Siemens S7-200 series PLC control system, it is a mature, stable, universal type of PLC, to suit a variety of automation applications, especially in manufacturing process control Application. Its modular, easy to implement distributed configuration and easy to master and so on, Siemens PLC control center has become a biological reaction process control implementation is economical and advanced control system, the system uses the touch screen display, on-site direct operations (menu type), all English menu and interface; also with the host computer for data transmission, data sampling and display tank, the system view of data analysis, reading settings. 10-inch LCD touch-sensitive screen as the display screen to display complete content-rich, user-friendly screen is simple, easy to operate. And disturbing each other. The control system can adapt to different range of sensors and actuators the output of the input signal with the signal anti-jamming system. Software: Siemens S7+ FORCE CONTORL Data collection and control module: Siemens S200 PLC controller and data collection and control module
1. Control
2. Measurement function: can feeding, bubble enemy, such as measurement of pH
4. Data Processing 5) data storage format is compatible with EXCEL, EXCEL platform can be to deal with
parameters; and the controller is not lost due to power settings for each parameter
9. show the controller is really running against, the panel instructed the state process system, process hardware, and motion status indicator for understanding the various devices (such as peristaltic pumps, circulating pumps, heating, mixing, etc.) work status, Fault identification can be used as display |
|
PC software
|
Control Software Ver8.0 is a data recording and processing as one of the fermentation of special packages, with the Chinese operation interface, data storage and backup, curve analysis, report generation analysis, anomaly analysis, for the fermentation and production process control and data processing bring a lot of convenience.
6. Report Printing
7. curve printing |
Specification
No |
Parameter |
Guideline |
Controller data processing function |
1 |
pH |
Displaying range: 0.00~14.00±0.01 Auto-control range:2.00~12.00±0.05 Fermentation process control (According to the fermentation time, auto- control pH fluent, at least10 parts) |
pH value historical and trend curve analysis Acid, alkali dosage curve analysis Batch report form analysis Acid, alkali total dosage record Keep and deliver data |
2 |
DO |
0-150±3%,Displaying precision: 0.1% It can be controlled by rev and feeding. Fermentation process control (According to the fermentation time, auto- control DO fluent, at least10 parts) |
DO value historical and trend curve analysis Batch report form analysis Keep and deliver data |
3 |
Antifoam |
Automatic PID control and alarm Fermentation process control (According to the fermentation time, auto- control antifoam fluent, at least10 parts) |
Antifoam value historical and trend curve analysis Foam error state record antifoam total dosage record Batch report form analysis Keep and deliver data |
4 |
Rev |
Automatic enactment and control Fermentation process control (According to the fermentation time, auto- control rev fluent, at least10 parts) |
Rev value historical and trend curve analysis Batch report form analysis Keep and deliver data |
5 |
Temperature |
Temperature of cooling water: +5℃-70℃±0.1℃ Fermentation process control (According to the fermentation time, auto- control temperature fluent, at least10 parts) |
Temperature value historical and trend curve analysis Batch report form analysis Keep and deliver data |
6 |
Feeding |
PID automatic enactment and control Fermentation process control (According to the fermentation time, auto- control feeding fluent, at least10 parts) |
Feeding value historical and trend curve analysis Feeding total dosage record Batch report form analysis Keep and deliver data |
7 |
Pressure |
Manual control, instrument display |
|
8 |
Air flux |
Manual control, instrument display |
Agitation |
Motor |
Top mount type AC geared motor |
Impellers |
Standard : Turbine impeller and Foam breaker (316L stainless steel) |
|
Control |
Inverter |
|
Materials & Finish |
Vessel |
Using 316L stainless steel to polishing. |
Piping |
316L stainless steel to prevent contamination. |
|
O-rings / Gaskets |
Viton or silicone material is used for the O-ring and the EPDM is used for gasket. |
|
Power Supply |
Controller system : 220V 50/60Hz, single phase Fermentor system : 440V~220V 50/60Hz, single and/or three phase |
|
Data Storage |
pH, DO, Pressure, Temperature and Agitation speed |
Vessel Selection or to tailor it according to customer's request
Total Vol. |
1000L |
1500L |
2000L |
3000L |
5000L |
10000L |
Working Vol. |
700L |
1000L |
1500L |
2000L |
3500L |
7000L |
Dia. : Height |
1:2 |
1:2 |
1:2 |
1:2 |
1:2 |
1:2 |
More informations, pls contact me by email or WhatsAPP or Skype, thank you!